Protein name:
Vinculin ;
Alternative:
Metavinculin (MV) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Exhibits self-association properties. Interacts with NRAP and SORBS1 (By similarity). Interacts with TLN1. Interacts with SYNM. Interacts with CTNNB1 and this interaction is necessary for its localization to the cell-cell junctions and for its function in regulating cell surface expression of E-cadherin.
Function:
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
Subcellular Location:
Cytoplasm
cytoskeleton
Cell junction
adherens junction
Cell membrane
Peripheral membrane protein
Cytoplasmic side
Cytoplasmic face of adhesion plaques. Recruitment to cell-cell junctions occurs in a myosin II-dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions.
Protein Attributes:
50:
MPVFHTRTIE | SILEPVAQQI | SHLVIMHEEG | EVDGKAIPDL | TAPVAAVQAA |
100:
VSNLVRVGKE | TVQTTEDQIL | KRDMPPAFIK | VENACTKLVQ | AAQMLQSDPY |
150:
SVPARDYLID | GSRGILSGTS | DLLLTFDEAE | VRKIIRVCKG | ILEYLTVAEV |
200:
VETMEDLVTY | TKNLGPGMTK | MAKMIDERQQ | ELTHQEHRVM | LVNSMNTVKE |
250:
LLPVLISAMK | IFVTTKNSKN | QGIEEALKNR | NFTVEKMSAE | INEIIRVLQL |
300:
TSWDEDAWAS | KDTEAMKRAL | ASIDSKLNQA | KGWLRDPSAS | PGDAGEQAIR |
350:
QILDEAGKVG | ELCAGKERRE | ILGTCKMLGQ | MTDQVADLRA | RGQGSSPVAM |
400:
QKAQQVSQGL | DVLTAKVENA | ARKLEAMTNS | KQSIAKKIDA | AQNWLADPNG |
450:
GPEGEEQIRG | ALAEARKIAE | LCDDPKERDD | ILRSLGEISA | LTSKLADLRR |
500:
QGKGDSPEAR | ALAKQVATAL | QNLQTKTNRA | VANSRPAKAA | VHLEGKIEQA |
550:
QRWIDNPTVD | DRGVGQAAIR | GLVAEGHRLA | NVMMGPYRQD | LLAKCDRVDQ |
600:
LTAQLADLAA | RGEGESPQAR | ALASQLQDSL | KDLKARMQEA | MTQEVSDVFS |
650:
DTTTPIKLLA | VAATAPPDAP | NREEVFDERA | ANFENHSGKL | GATAEKAAAV |
700:
GTANKSTVEG | IQASVKTARE | LTPQVVSAAR | ILLRNPGNQA | AYEHFETMKN |
750:
QWIDNVEKMT | GLVDEAIDTK | SLLDASEEAI | KKDLDKCKVA | MANIQPQMLV |
800:
AGATSIARRA | NRILLVAKRE | VENSEDPKFR | EAVKAASDEL | SKTISPMVMD |
850:
AKAVAGNISD | PGLQKSFLDS | GYRILGAVAK | VREAFQPQEP | DFPPPPPDLE |
900:
QLRLTDELAP | PKPPLPEGEV | PPPRPPPPEE | KDEEFPEQKA | GEVINQPMMM |
950:
AARQLHDEAR | KWSSKPGIPA | AEVGIGVVAE | ADAADAAGFP | VPPDMEDDYE |
1000:
PELLLMPSNQ | PVNQPILAAA | QSLHREATKW | SSKGNDIIAA | AKRMALLMAE |
1050:
MSRLVRGGSG | TKRALIQCAK | DIAKASDEVT | RLAKEVAKQC | TDKRIRTNLL |
1100:
QVCERIPTIS | TQLKILSTVK | ATMLGRTNIS | DEESEQATEM | LVHNAQNLMQ |
1134:
SVKETVREAE | AASIKIRTDA | GFTLRWVRKT | PWYQ
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Chicken
Pig
Human
Mouse
ELISA Kit for Human Vinculin
ELISA Kit for Human Vinculin
ELISA Kit for Human Vinculin
ELISA Kit for Human Vinculin
ELISA Kit for Human Vinculin
CLIA Kit for Human Vinculin
CLIA Kit for Human Vinculin
CLIA Kit for Human Vinculin
CLIA Kit for Human Vinculin
CLIA Kit for Human Vinculin
Polyclonal Antibody for Human Vinculin
Polyclonal Antibody for Human Vinculin
Polyclonal Antibody for Human Vinculin
Polyclonal Antibody for Human Vinculin
Polyclonal Antibody for Human Vinculin
Monoclonal Antibody for Human Vinculin
Monoclonal Antibody for Human Vinculin
Monoclonal Antibody for Human Vinculin
Monoclonal Antibody for Human Vinculin
Monoclonal Antibody for Human Vinculin
Protein for Human Vinculin
Protein for Human Vinculin
Protein for Human Vinculin
Protein for Human Vinculin
Protein for Human Vinculin
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Endothelial cell .
2.
"The full-ORF clone resource of the German cDNA consortium."
Bechtel S.
,
Rosenfelder H.
,
Duda A.
,
Schmidt C.P.
,
Ernst U.
,
Wellenreuther R.
,
Mehrle A.
,
Schuster C.
,
Bahr A.
,
Bloecker H.
,
Heubner D.
,
Hoerlein A.
,
Michel G.
,
Wedler H.
,
Koehrer K.
,
Ottenwaelder B.
,
Poustka A.
,
Wiemann S.
,
Schupp I.
more...
BMC Genomics8:399-399(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue :
Retina .
3.
"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P.
,
Earthrowl M.E.
,
Grafham D.V.
,
Rubenfield M.
,
French L.
,
Steward C.A.
,
Sims S.K.
,
Jones M.C.
,
Searle S.
,
Scott C.
,
Howe K.
,
Hunt S.E.
,
Andrews T.D.
,
Gilbert J.G.R.
,
Swarbreck D.
,
Ashurst J.L.
,
Taylor A.
,
Battles J.
,
Bird C.P.
,
Ainscough R.
,
Almeida J.P.
,
Ashwell R.I.S.
,
Ambrose K.D.
,
Babbage A.K.
,
Bagguley C.L.
,
Bailey J.
,
Banerjee R.
,
Bates K.
,
Beasley H.
,
Bray-Allen S.
,
Brown A.J.
,
Brown J.Y.
,
Burford D.C.
,
Burrill W.
,
Burton J.
,
Cahill P.
,
Camire D.
,
Carter N.P.
,
Chapman J.C.
,
Clark S.Y.
,
Clarke G.
,
Clee C.M.
,
Clegg S.
,
Corby N.
,
Coulson A.
,
Dhami P.
,
Dutta I.
,
Dunn M.
,
Faulkner L.
,
Frankish A.
,
Frankland J.A.
,
Garner P.
,
Garnett J.
,
Gribble S.
,
Griffiths C.
,
Grocock R.
,
Gustafson E.
,
Hammond S.
,
Harley J.L.
,
Hart E.
,
Heath P.D.
,
Ho T.P.
,
Hopkins B.
,
Horne J.
,
Howden P.J.
,
Huckle E.
,
Hynds C.
,
Johnson C.
,
Johnson D.
,
Kana A.
,
Kay M.
,
Kimberley A.M.
,
Kershaw J.K.
,
Kokkinaki M.
,
Laird G.K.
,
Lawlor S.
,
Lee H.M.
,
Leongamornlert D.A.
,
Laird G.
,
Lloyd C.
,
Lloyd D.M.
,
Loveland J.
,
Lovell J.
,
McLaren S.
,
McLay K.E.
,
McMurray A.
,
Mashreghi-Mohammadi M.
,
Matthews L.
,
Milne S.
,
Nickerson T.
,
Nguyen M.
,
Overton-Larty E.
,
Palmer S.A.
,
Pearce A.V.
,
Peck A.I.
,
Pelan S.
,
Phillimore B.
,
Porter K.
,
Rice C.M.
,
Rogosin A.
,
Ross M.T.
,
Sarafidou T.
,
Sehra H.K.
,
Shownkeen R.
,
Skuce C.D.
,
Smith M.
,
Standring L.
,
Sycamore N.
,
Tester J.
,
Thorpe A.
,
Torcasso W.
,
Tracey A.
,
Tromans A.
,
Tsolas J.
,
Wall M.
,
Walsh J.
,
Wang H.
,
Weinstock K.
,
West A.P.
,
Willey D.L.
,
Whitehead S.L.
,
Wilming L.
,
Wray P.W.
,
Young L.
,
Chen Y.
,
Lovering R.C.
,
Moschonas N.K.
,
Siebert R.
,
Fechtel K.
,
Bentley D.
,
Durbin R.M.
,
Hubbard T.
,
Doucette-Stamm L.
,
Beck S.
,
Smith D.R.
,
Rogers J.
more...
Nature429:375-381(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT LEU-234
tissue :
Prostate .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-56;ALTERNATIVE SPLICING (ISOFORMS 1 AND 2)
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 114-132; 247-261; 327-339; 353-366; 465-476 AND 548-561;IDENTIFICATION BY MASS SPECTROMETRY
tissue :
Fetal brain cortex .
7.
"An additional exon in the human vinculin gene specifically encodes meta-vinculin-specific difference peptide. Cross-species comparison reveals variable and conserved motifs in the meta-vinculin insert."
Koteliansky V.E.
,
Ogryzko E.P.
,
Zhidkova N.I.
,
Weller P.A.
,
Critchley D.R.
,
Vancompernolle K.
,
Vandekerckhove J.
,
Strasser P.
,
Way M.
,
Gimona M.
,
Small J.V.
Eur. J. Biochem.204:767-772(1992)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 854-1051;ALTERNATIVE SPLICING (ISOFORM 2)
tissue :
Uterus .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 2-7 (ISOFORMS 1/2)
tissue :
Platelet .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT TYR-1133;IDENTIFICATION BY MASS SPECTROMETRY
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-721;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SYNM
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-290; SER-721 AND TYR-822;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-173 AND LYS-496;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DOMAIN
16.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
Miller M.L.
,
Jensen L.J.
,
Gnad F.
,
Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288; SER-290 AND SER-721;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-290; SER-346; SER-434 AND SER-721;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION (ISOFORM 2)
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.42 ANGSTROMS) OF 1-258 IN COMPLEX WITH TLN1
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 1-258 IN COMPLEX WITH TLN1
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS CMD1W LEU-954 DEL AND TRP-975;CHARACTERIZATION OF VARIANT CMD1W TRP-975
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT CMD1W TRP-975;VARIANTS VAL-934 AND ALA-943
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT CMH15 MET-277